Antioxidant, Antimicrobial Properties and In Silico Study of a N,N'-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine)

ABSTRACT This study aimed to determine the antibacterial and antioxidant activities of newly synthesized Schiff base support laboratory results with molecular modeling studies. Antibacterial activity schiff bases was demonstrated using Gram (-) Pseudomonas aeruginosa Acinetobacter baumannii bacterial strains. Minimum Inhibition Concentration (MIC) values were determined evaluate their antimicrobial against Gram-negative P. A.baumanni In experiments, responses DPPH ABTS radicals calculated at certain concentration ranges graphs drawn. For study, Autodock Vina Discovery Studio 2020 package programs used. The observed inhibition variable depending on clinical isolate tested samples. highest achieved 75 μl -100 μl. N,N'-(ethane-1,2-diyl)bis(1-(9H-fluoren-2-yl)methanimine) Molecular docking show that N,N'-(ethane-1,2-diyl)bis(1(9H-fluoren-2-yl) methanimine) binds strongly 4ZIY 4ZHU structures. It has been proven by ligand antibiotic resistance properties. N, N'-(ethane-1,2-diyl)bis(1-(9Hfluoren-2-yl) synthesis compound showed moderate A. is known have strong biological activity. this it can be said addition, our supported modeling. Our findings taken a higher level in vivo vitro